李汉杰博士/研究员

肿瘤免疫学、合成免疫学、单细胞组学、T细胞生物学。

李汉杰博士,深圳市孔雀计划人才(B类),国家重点研发专项项目首席科学家。2014年在韩家淮院士的指导下获得厦门大学博士学位。2016年至2020年在以色列魏茨曼科学研究所从事免疫学和单细胞组学研究工作。合作导师为霍华德休斯医学研究院研究员,EMBO院士Ido Amit教授。曾被评为德国 “洪堡学者”,获得欧盟 “玛丽-居里奖学金”。至今已于免疫学领域发表多篇高水平论文,其中作为第一/通讯作者在Cell、Cell Research、Cell Reports、Journal of Immunology、Cellular & Molecular Immunology、Journal of Leukocyte Biology期刊发表多篇论文,合作作者论文发表于Science和Cell等期刊。

实验室整合单细胞组学、计算生物学、分子细胞生物学深入研究免疫系统在肿瘤、自身免疫病、病毒感染等疾病中的作用。还将利用合成生物学手段对免疫细胞、分子、信号通路进行重设计,实现基于免疫系统的疾病诊疗。

联系邮箱:hj.li@siat.ac.cn


论文发表节选


Hanjie Li#, Anne M van der Leun#, Ido Yofe#, Yaniv Lubling#, Dikla Gelbard-Solodkin, Alexander C J van Akkooi, Marlous van den Braber, Elisa A Rozeman, John B A G Haanen, Christian U Blank, Hugo M Horlings, Eyal David, Yael Baran, Akhiad Bercovich, Aviezer Lifshitz, Ton N Schumacher*, Amos Tanay*, Ido Amit*, Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment Within Human Melanoma, Cell, 2019, 176(4): 775-789

Hanjie Li, Congting Ye, Guoli Ji, Jiahuai Han, Determinants of Public T Cell Responses, Cell Research, 2012, 22(1): 33-42

Hanjie Li#, Qiuyu Zhuang#, Yuze Wang#, Tianying Zhang, Jinghua Zhao, Yali Zhang, Junfang Zhang, Yi Lin, Quan Yuan, Ningshao Xia*, Jiahuai Han*, HBV Life Cycle Is Restricted in Mouse Hepatocytes Expressing Human NTCP, Cellular & Molecular Immunology, 2014, 11(2): 175-83

Hanjie Li#, Congting Ye#, Guoli Ji, Xiaohui Wu, Zhe Xiang, Yuanyue Li, Yonghao Cao, Xiaolong Liu, Daniel C Douek, David A Price*, Jiahuai Han*, Recombinatorial Biases and Convergent Recombination Determine Interindividual TCRβ Sharing in Murine Thymocytes, Journal of Immunology, 2012, 189(5): 2404-13

Juan Lin#, Hanjie Li#, Min Yang, Junming Ren, Zhe Huang, Felicia Han, Jian Huang, Jianhui Ma, Duanwu Zhang, Zhirong Zhang, Jianfeng Wu, Deli Huang, Muzhen Qiao, Guanghui Jin, Qiao Wu, Yinghui Huang, Jie Du*, Jiahuai Han*, A Role of RIP3-mediated Macrophage Necrosis in Atherosclerosis Development, Cell Reports, 2013, 3(1): 200-210