利用新型质谱等多种技术系统性研究免疫细胞关键信号转导网络的分子结构机制,并进一步设计新型合成免疫学疗法。
施小山博士,研究员,2009年获得上海交通大学生物技术学士;2015年获得中科院上海生化细胞所生物化学与分子生物学博士,导师为许琛琦研究员,研究课题为T细胞抗原受体的信号转导机制;2016年至2021年于美国加州大学伯克利分校James Hurley实验室进行博士后研究,研究课题为ULK1复合物起始调控自噬过程机制。施小山博士已在Nature、Cell、JCB、eLife、PNAS等期刊发表多篇论文,并获得吴瑞奖、中科院优秀博士学位论文奖等学术奖励。
施小山课题组主要研究方向为利用新型质谱等多种技术系统性研究免疫细胞关键信号转导网络的分子结构机制,并进一步设计新型合成免疫学疗法。
联系邮箱:xs.shi@siat.ac.cn
论文发表节选
Xiaoshan Shi#; Yunchen Bi#; Wei Yang#; Xingdong Guo; Yan Jiang; Chanjuan Wan; Lunyi Li; Yibing Bai; Jun Guo; Yujuan Wang; Xiangjun Chen; Bo Wu; Hongbin Sun; Wanli Liu; Junfeng Wang*; Chenqi Xu*; Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids, Nature, 2013, 493(7430): 111-115.
Lunyi Li#; Xiaoshan Shi#; Xingdong Guo; Hua Li; Chenqi Xu*; Ionic protein–lipid interaction at the plasma membrane: what can the charge do?, Trends in Biochemical Sciences, 2014, 39(3): 130-140.
Lunyi Li#; Xingdong Guo#; Xiaoshan Shi#; Changting Li#; Wei Wu; Chengsong Yan; Haopeng Wang; Hua Li; Chenqi Xu*; Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling, Proceedings of the National Academy of Sciences of the United States of America, 2017, 114(29): E5891-E5899.
Wei Wu#; Qiuping Zhou#; Takeya Masubuchi#; Xiaoshan Shi#; Hua Li; Xinyi Xu; Min Huang; Li Meng; Xing He; Hengyu Zhu; Shuaixin Gao; Nan Zhang; Ruirui Jing; Jie Sun; Haopeng Wang; Enfu Hui*; Catherine Chiulan Wong*; Chenqi Xu*; Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy, Cell, 2020, 182(4): 855-871.
Xiaoshan Shi#; Adam L. Yokom#; Chunxin Wang; Lindsey N. Young; Richard J. Youle; James H. Hurley*; ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer, Journal of Cell Biology, 2020, 219(7): e201911047.
Xiaoshan Shi#; Chunmei Chang#; Adam L. Yokom#; Liv E. Jensen; James H. Hurley*; The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment, eLife, 2020, 9: e59099.
Chunmei Chang; Xiaoshan Shi; Liv E. Jensen; Adam L. Yokom; Dorotea Fracchiolla; Sascha Martens; James H. Hurley*; Reconstitution of cargoinduced LC3 lipidation in mammalian selective autophagy, Science Advances, 2021, 7(17): eabg4922.